Immunogenicity and protectivity of intranasally delivered vector-based heterologous prime-boost COVID-19 vaccine Sputnik V in mice and non-human primatesArticle Published on 2022-12-012022-11-15 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] accompanied Blood clinical investigation Coverage COVID-19 COVID-19 pandemic COVID-19 vaccine cytokine release Diseases effective effort elicit Gam-COVID-Vac Health heterologous prime-boost IgA antibody IgG immune response Immunity immunization immunogenic immunogenicity Infection intranasal intranasal vaccine. intranasally K18-hACE2 transgenic mice less lung immunopathology mice mononuclear cell Mortality mucosal nasal mucosa neutralizing antibody non-human primate pandemic Peripheral blood Prevent proliferation protective immunity provided revaccination robust SARS-CoV-2 SARS-COV-2 infection SARSCoV-2 serum Sputnik V systemic and local the vaccine Transmission vaccination Vaccination strategy Vaccine vaccine candidate variants of concern virus virus infection virus spread [DOI] 10.1080/22221751.2022.2119169 PMC 바로가기
Differential transcriptomic landscapes of multiple organs from SARS-CoV-2 early infected rhesus macaquesSARS-CoV-2 초기 감염된 붉은털 원숭이의 여러 기관의 차등 전사체 풍경Article Published on 2022-12-012022-09-11 Journal: Protein & Cell [Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단, [키워드] accompanied analyzed Angiogenesis cause Central nervous system cerebral cortex changes in clinical complications clinical manifestation clinical manifestations CNS Coagulation controls drastic dysregulation early infection elevated Encephalitis evidenced examined exhibited expression expressions Factor fibrosis function Genes hyperinflammatory state immune response immune responses infected with SARS-CoV-2 Infection Inflammation inflammation response Inflammatory factor inflammatory factors mechanism multiple organ neuropilin 1 NRP1 organs positive positive feedback post infection provide receptor rhesus rhesus macaque right ventricle SARS-CoV-2 SARS-COV-2 infection significantly tissue tissues transcriptomic transcriptomic alteration Transmission up-regulated upregulation Viral viral encephalitis viral encephalitis. [DOI] 10.1007/s13238-022-00915-5 PMC 바로가기 [Article Type] Article
Induction of pulmonary HLA-G expression by SARS-CoV-2 infectionArticle Published on 2022-11-052022-11-15 Journal: Cellular and Molecular Life Sciences [Category] SARS, 치료기술, 치료제, [키워드] accompanied Antigen Autopsy biopsies CD8 Cell changes in correlated distribution epithelial cell Evidence expressed expression expression level Frequency heart muscle HLA-G Hyperactivation Immune cell Immune cell infiltration immune cells Immune escape immune response induction information kidney leukocyte lung lung alveolar lung epithelia lung epithelial cell lung tissue Macrophage marker microRNA microRNA. miRNA miRNA expression modulating organs other organ patients protein expression SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 nucleocapsid SARS-CoV-2- SARS-CoV-2-infected patient specimen Spike protein surgical T cell responses T cells therapeutic target tissue tissues Treatment Tumor virus-infected cells while [DOI] 10.1007/s00018-022-04592-9 PMC 바로가기
SARS-CoV-2 infects human brain organoids causing cell death and loss of synapses that can be rescued by treatment with SofosbuvirArticle Published on 2022-11-032022-11-15 Journal: PLoS Biology [Category] SARS, 치료제, [키워드] accompanied Affect alleviate alteration Antiviral antivirals Brain brain organoid brain organoids cell death cells cellular coronavirus 2 coronavirus disease cortical COVID-19 death determine drug excitatory food infect inhibit SARS-CoV-2 neurological manifestation Neurological symptoms neuronal neurons Newborn pandemic phenotype promote replicate Replication rescued respiratory respiratory illnesses SARS-CoV-2 sofosbuvir Treatment underlie variety WHO World Health Organization [DOI] 10.1371/journal.pbio.3001845 PMC 바로가기
Modelling optimal vaccination strategies against COVID-19 in a context of Gamma variant predominance in BrazilArticle Published on 2022-11-022022-11-16 Journal: Vaccine [Category] COVID19(2023년), SARS, 변종, [키워드] accompanied age AZD1222 Brazil circulating variant Coverage COVID-19 death deaths dose driven by Effectiveness Epidemic estimates evaluate evaluated Evidence Gamma group groups Guidance health system immunization immunization strategy implementation increase in inefficient initial International interval Local modelling Older age outcome populations reached reducing required subsequent Support vaccination Vaccination strategy Vaccine vaccine availability Vaccines. variant variants of concern VoC [DOI] 10.1016/j.vaccine.2022.09.082 PMC 바로가기
Development of IgA vasculitis with severe glomerulonephritis after COVID-19 vaccination: a case report and literature reviewArticle Published on 2022-11-012022-11-15 Journal: CEN case reports [Category] 진단, [키워드] accompanied Acute kidney injury administration applied Case report COVID-19 COVID-19 pandemic COVID-19 vaccination COVID-19 vaccine Cyclophosphamide development Glomerulonephritis Hematuria IgA IgA Vasculitis IgAV. Immunosuppressive treatment initial injection Intensive intractable intravenous Japanese kidney literature review nephropathy oral steroid Patient performed Pfizer-BioNTech pulse purpura remained renal function reported resolved second dose second vaccination Spread syndrome Treatment Vasculitis [DOI] 10.1007/s13730-022-00695-1 PMC 바로가기
SARS-CoV-2 infects neurons and induces neuroinflammation in a non-human primate model of COVID-19Article Published on 2022-11-012022-11-15 Journal: Cell Reports [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] accompanied acute respiratory syndrome astrocytes Brain cellular mechanism CNS coronavirus coronavirus disease COVID-19 CP: Microbiology CP: Neuroscience Diabetic exacerbated High-resolution induce infect Infection initial investigated macaque microglia Microscopy modulated molecular Neuroinflammation Neurological complication Neurological complications Neuron neuronal neurotropism NHP non-human primate model olfactory patients plethora provide reducing Region rhesus rhesus. robust SARS-CoV-2 systemic inflammatory response triggered [DOI] 10.1016/j.celrep.2022.111573 PMC 바로가기
Delayed encephalopathy after COVID-19: A case series of six patientsArticle Published on 2022-10-212022-11-15 Journal: Medicine [Category] 진단, [키워드] absence accompanied acute respiratory syndrome Administered age autoantibody case sery cerebrospinal fluid characterized Computed tomography contribute coronavirus coronavirus disease COVID-19 CSF Delayed demonstrated disturbance of consciousness Duration dysfunction electroencephalogram elevated Encephalopathy evaluated female Hospitalization Immunoglobulin Immunotherapy interleukin-6 lacunar infarction magnetic resonance imaging males moderate MOST neurological Neurological deficit occur Pathogenesis Patient patients polymerase chain protein level pulse ranged remained Repeat resolved reverse transcription serum severity of COVID-19 Symptom Treatment with COVID-19 worsening [DOI] 10.1097/MD.0000000000031029 PMC 바로가기
Inflammatory myopathy following coronavirus disease 2019 vaccination: A systematic reviewArticle Published on 2022-10-212022-11-15 Journal: Frontiers in Public Health [Category] 진단, [키워드] accompanied adverse event antibodies article autoantibodies autoantibody BNT162b2 ChAdOx1 Clinical course clinical feature complications composed conducted coronavirus disease coronavirus disease 2019 vaccine COVID-19 COVID-19 vaccination COVID-19 vaccine critical appraisal dermatomyositis Follow-up identify Immune-mediated IMPROVE independent induce Inflammatory inflammatory myopathy investigator Joanna Briggs Institute management muscular myositis myositis specific autoantibodies. occurred Onset Patient patients presenting proportion report reported Risk of bias SARS-CoV-2 SARS-CoV-2 vaccine searched Side effect skin rash Specific subtype Symptom systematic review Treatment vaccination Vaccine vaccine dose weakness were used [DOI] 10.3389/fpubh.2022.1007637 PMC 바로가기
Synthesis and Anticancer and Antiviral Activities of C-2′-Branched ArabinonucleosidesArticle Published on 2022-10-192022-11-15 Journal: International Journal of Molecular Sciences [Category] 치료제, [키워드] accompanied activity Analysis anti-SARS-CoV-2 anti-tumor Antiviral antiviral activity Cell cell line Concentration coronavirus cytotoxicity Effect functional Generation time group growth HaCaT immortalized inhibitory activity investigated morphological changes MTT nucleoside nucleoside analogue outcome parameter photocatalytic thiol-ene reaction Reactions SAR SARS-CoV-2 SCC synthesis time-lapse imaging. tumor cells tumorous was obtained [DOI] 10.3390/ijms232012566 PMC 바로가기